Biotransformation of BMOV in the presence of blood serum proteins.

نویسندگان

  • Daniele Sanna
  • Linda Bíró
  • Péter Buglyó
  • Giovanni Micera
  • Eugenio Garribba
چکیده

The interaction of the potent anti-diabetic agent bis(maltolato)oxidovanadium(IV) (BMOV) with some proteins of blood serum was studied by EPR spectroscopy, pH-potentiometry and DFT calculations. The formation of cis-VO(ma)(2)(hTf), cis-VO(ma)(2)(HSA) and cis-VO(ma)(2)(IgG), their role in the biotransformation in vivo and the mechanism of transport of BMOV in blood are discussed.

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عنوان ژورنال:
  • Metallomics : integrated biometal science

دوره 4 1  شماره 

صفحات  -

تاریخ انتشار 2012